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KMID : 0043319950180060423
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Archives of Pharmacal Research
1995 Volume.18 No. 6 p.423 ~ p.426
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In vitro and in vivo Activities of SM-101, a Micture of Metampicillin and Sulbactam
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Choi Keum-Hwa
Kim Sook-Kyung
Baek Moon-Chang
Kim Byung-Kak
Lee Dong-Young
Choi Eung-Chil
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Abstract
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SM-101 is a mixture of metampicillin and sulbactam(2:1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activities against major strains. Except P. anruginosa and S. marcescens, the in vitro antibacterial activity of SM-101 was higher than those of metampicillin, piperacillin and Augmentin against Staphylococcus spp., Streptococcus spp., Moganella morganii, E. Coil, and Proteus spp. The values of SM-101 were two-fold or greater than those of metampicillin, piperacillin and Augmentin against producing strains, p. mirabilis GN79 and M. morganiii MB4-11. The in vivo efficacy of SM-101 was more active than metampicillin and pipeeracillin and similar to Augmentin against S. aureus Smith, E coli MB4-01 and K. pneumoniae MB4-02.
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KEYWORD
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SM-101, Antibacterial activity, Sulbactam, Metampicillin, Lactamase, ED50
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